SVHC

Candidate List of Substances of Very High Concern for authorization

Updated 241 / 27-JUN-2024

 

                  This list is the European Union’s Directive 1907/2006 (REACH) of SVHC’s (Substances of

Very High Concern). There are 235 substances total, organized in sections of the month and year

that they were official placed on the candidate list. Inclusion on this list does not necessarily mean

that these substances are banned in the EU but have been included for future study and action.

Click here to see the ECHA website and follow up on these substances.

 

 

รายชื่อ Candidate List of Substances of Very High Concern for authorization 241 มีดังนี้

 

  Substance Name EC Number CAS Number Date of inclusion Reason for inclusion Decision number
1 Bis(α,α-dimethylbenzyl) peroxide  201-279-3 80-43-3 2024/6/27 Toxic for reproduction (Article 57c) D(2024)4144-DC
2 2,4,6-tri-tert-butylphenol  211-989-5 732-26-3 2024/1/23 Toxic for reproduction (Article 57c)
Persistent, bioaccumulative and toxic (PBT) 
(Article 57d)
D(2023)8585-DC
3 2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol 221-573-5 3147-75-9 2024/1/23 Very persistent and very bioaccumulative (vPvB)
(Article 57e)
D(2023)8585-DC
4 2-(dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4-(morpholin-4-yl)phenyl]butan-1-one  438-340-0 119344-86-4 2024/1/23 Toxic for reproduction (Article 57c) D(2023)8585-DC
5 Bumetrizole 223-445-4 3896-11-5 2024/1/23 vPvB (Article 57e) D(2023)8585-DC
6 Oligomerisation and alkylation reaction products of 2-phenylpropene and phenol  700-960-7 - 2024/1/23  vPvB (Article 57e) D(2023)8585-DC
7 Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide 278-355-8 75980-60-8 2023/6/14 Toxic for reproduction (Article 57c)  D(2023)3788-DC 
8 Bis(4-chlorophenyl) sulphone  201-247-9 80-07-9 2023/6/14 vPvB (Article 57e) D(2023)3788-DC 
9 reaction mass of 2,2,3,3,5,5,6,6-octafluoro-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)morpholine and 2,2,3,3,5,5,6,6-octafluoro-4-(heptafluoropropyl)morpholine 473-390-7 - 2023/1/17 vPvB (Article 57e) D(2022)9120-DC
10 Perfluoroheptanoic acid and its salts - - 2023/1/17 Toxic for reproduction (Article 57c)#PBT (Article 57d)#vPvB (Article 57e)#Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)#Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment) D(2022)9120-DC
11 Melamine 203-615-4 108-78-1 2023/1/17 Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)#Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment) D(2022)9120-DC
12 Isobutyl 4-hydroxybenzoate 224-208-8 4247-02-3 2023/1/17 Endocrine disrupting properties (Article 57(f) - human health) D(2022)9120-DC
13 bis(2-ethylhexyl) tetrabromophthalate covering any of the individual isomers and/or combinations thereof - - 2023/1/17 vPvB (Article 57e) D(2022)9120-DC
14 Barium diboron tetraoxide 237-222-4 13701-59-2 2023/1/17 Toxic for reproduction (Article 57c) D(2022)9120-DC
15 4,4'-sulphonyldiphenol 201-250-5 80-09-1 2023/1/17 Toxic for reproduction (Article 57c)#Endocrine disrupting properties (Article 57(f) - environment)#Endocrine disrupting properties (Article 57(f) - human health) D(2022)9120-DC
16 2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol 201-236-9 79-94-7 2023/1/17 Carcinogenic (Article 57a) D(2022)9120-DC
17 1,1'-[ethane-1,2-diylbisoxy]bis[2,4,6-tribromobenzene] 253-692-3 37853-59-1 2023/1/17 vPvB (Article 57e) D(2022)9120-DC
18 N-(hydroxymethyl)acrylamide 213-103-2 924-42-5 2022/6/10 Carcinogenic (Article 57a)
Mutagenic (Article 57b)
D(2022)4187-DC
19 tris(2-methoxyethoxy)vinylsilane 213-934-0 1067-53-4 2022/1/17 Toxic for reproduction (Article 57c) D(2021)10043-DC
20 S-(tricyclo(5.2.1.0'2,6)deca-3-en-8(or 9)-yl O-(isopropyl or isobutyl or 2-ethylhexyl) O-(isopropyl or isobutyl or 2-ethylhexyl) phosphorodithioate 401-850-9 255881-94-8 2022/1/17 PBT (Article 57d) D(2021)10043-DC
21 6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol 204-327-1 119-47-1 2022/1/17 Toxic for reproduction (Article 57c) D(2021)10043-DC
22 (±)-1,7,7-trimethyl-3-[(4-methylphenyl)methylene]bicyclo[2.2.1]heptan-2-one covering any of the individual isomers and/or combinations thereof (4-MBC) - - 2022/1/17 Endocrine disrupting properties (Article 57(f) - human health) D(2021)10043-DC
23 Phenol, alkylation products (mainly in para position) with C12-rich branched alkyl chains from oligomerisation, covering any individual isomers and/ or combinations thereof (PDDP) - - 2021/7/8 Toxic for reproduction (Article 57c) D(2021)4569-DC
24 orthoboric acid, sodium salt - - 2021/7/8 Toxic for reproduction (Article 57c) D(2021)4569-DC
25 Medium-chain chlorinated paraffins (MCCP) - - 2021/7/8 PBT (Article 57d) D(2021)4569-DC
26 glutaral 203-856-5 111-30-8 2021/7/8 Respiratory sensitising properties (Article 57(f) - human health) D(2021)4569-DC
27 4,4'-(1-methylpropylidene)bisphenol 201-025-1 77-40-7 2021/7/8 Endocrine disrupting properties (Article 57(f) - environment)
Endocrine disrupting properties (Article 57(f) - human health)
D(2021)4569-DC
28 2-(4-tert-butylbenzyl)propionaldehyde and its individual stereoisomers - - 2021/7/8 Toxic for reproduction (Article 57c) D(2021)4569-DC
29 2,2-bis(bromomethyl)propane-1,3-diol (BMP); 2,2-dimethylpropan-1-ol, tribromo derivative/3-bromo-2,2-bis(bromomethyl)-1-propanol (TBNPA); 2,3-dibromo-1-propanol (2,3-DBPA) - - 2021/7/8 Carcinogenic (Article 57a) D(2021)4569-DC
30 1,4-dioxane 204-661-8 123-91-1 2021/7/8 Carcinogenic (Article 57a)
Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
D(2021)4569-DC
31 Bis(2-(2-methoxyethoxy)ethyl)ether 205-594-7 143-24-8 2021/1/19 Toxic for reproduction (Article 57c) D(2020)9139-DC
32 Dioctyltin dilaurate, stannane, dioctyl-, bis(coco acyloxy) derivs., and any other stannane, dioctyl-, bis(fatty acyloxy) derivs. wherein C12 is the predominant carbon number of the fatty acyloxy moiety - - 2021/1/19 Toxic for reproduction (Article 57c) D(2020)9139-DC
33 Dibutylbis(pentane-2,4-dionato-O,O')tin 245-152-0 22673-19-4 2020/6/25 Toxic for reproduction (Article 57c) D(2020)4578-DC
34 butyl 4-hydroxybenzoate 202-318-7 94-26-8 2020/6/25 Endocrine disrupting properties (Article 57(f) - human health) D(2020)4578-DC
35 2-methylimidazole 211-765-7 693-98-1 2020/6/25 Toxic for reproduction (Article 57c) D(2020)4578-DC
36 1-vinylimidazole 214-012-0 1072-63-5 2020/6/25 Toxic for reproduction (Article 57c) D(2020)4578-DC
37 Perfluorobutane sulfonic acid (PFBS) and its salts - - 2020/1/16 Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
ECHA/01/2020
38 Diisohexyl phthalate 276-090-2 71850-09-4 2020/1/16 Toxic for reproduction (Article 57c) ECHA/01/2020
39 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one 400-600-6 71868-10-5 2020/1/16 Toxic for reproduction (Article 57c) ECHA/01/2020
40 2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone 404-360-3 119313-12-1 2020/1/16 Toxic for reproduction (Article 57c) ECHA/01/2020
41 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, its salts and its acyl halides
(covering any of their individual isomers and combinations thereof)
- - 2019/7/16 Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
ED/71/2019
42 2-methoxyethyl acetate 203-772-9 110-49-6 2019/7/16 Toxic for reproduction (Article 57c) ED/71/2019
43 4-tert-butylphenol 202-679-0 98-54-4 2019/7/16 Endocrine disrupting properties (Article 57(f) - environment) ED/71/2019
EU/2019/1194
44 Tris(4-nonylphenyl, branched and linear) phosphite (TNPP) with ≥ 0.1% w/w of 4-nonylphenol, branched and linear (4-NP) - - 2019/7/16 Endocrine disrupting properties (Article 57(f) - environment) ED/71/2019
45 1,7,7-trimethyl-3-(phenylmethylene)bicyclo[2.2.1]heptan-2-one 239-139-9 15087-24-8 2019/1/15 Endocrine disrupting properties (Article 57(f) - environment) ED/88/2018
EU/2018/2013
46 2,2-bis(4'-hydroxyphenyl)-4-methylpentane 401-720-1 6807-17-6 2019/1/15 Toxic for reproduction (Article 57c) ED/88/2018
47 Benzo[k]fluoranthene 205-916-6 207-08-9 2019/1/15 Carcinogenic (Article 57a)
PBT (Article 57d)
vPvB (Article 57e)
ED/88/2018
48 Fluoranthene 205-912-4 206-44-0
93951-69-0
2019/1/15 PBT (Article 57d)
vPvB (Article 57e)
ED/88/2018
49 Phenanthrene 201-581-5 85-01-8 2019/1/15 vPvB (Article 57e) ED/88/2018
50 Pyrene 204-927-3 129-00-0
1718-52-1
2019/1/15 PBT (Article 57d)
vPvB (Article 57e)
ED/88/2018
51 Benzene-1,2,4-tricarboxylic acid 1,2 anhydride ; trimellitic anhydride; TMA 209-008-0 552-30-7 2018/6/27 Respiratory sensitising properties (Article 57(f) - human health) ED/61/2018
EU/2018/594
52 Benzo[ghi]perylene 205-883-8 191-24-2 2018/6/27 PBT (Article 57d)
vPvB (Article 57e)
ED 61/2018
53 Decamethylcyclopentasiloxane 208-764-9 541-02-6 2018/6/27 PBT (Article 57d)
vPvB (Article 57e)
ED 61/2018
54 Dicyclohexyl phthalate ; DCHP 201-545-9 84-61-7 2018/6/27 Toxic for reproduction (Article 57c)
Endocrine disrupting properties (Article 57(f) - human health)
EU/2018/636
ED/61/2018
55 Disodium octaborate 234-541-0 12008-41-2 2018/6/27 Toxic for reproduction (Article 57c) ED 61/2018
56 Dodecamethylcyclohexasiloxane 208-762-8 540-97-6 2018/6/27 PBT (Article 57d)
vPvB (Article 57e)
ED 61/2018
57 Ethylenediamine ; EDA 203-468-6 107-15-3 2018/6/27 Respiratory sensitising properties (Article 57(f) - human health) ED 61/2018
58 Lead 231-100-4 7439-92-1 2018/6/27 Toxic for reproduction (Article 57c) ED 61/2018
59 Octamethylcyclotetrasiloxane 209-136-7 556-67-2 2018/6/27 PBT (Article 57d)
vPvB (Article 57e)
ED 61/2018
60 Terphenyl, hydrogenated 262-967-7 61788-32-7 2018/6/27 vPvB (Article 57e) ED 61/2018
61 Benz[a]anthracene 200-280-6 56-55-3
1718-53-2
2018/1/15 Carcinogenic (Article 57a)
PBT (Article 57d)
vPvB (Article 57e)
ED 01/2018
62 Cadmium carbonate 208-168-9 513-78-0 2018/1/15 Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
ED 01/2018
63 Cadmium hydroxide 244-168-5 21041-95-2 2018/1/15 Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
ED 01/2018
64 Cadmium nitrate 233-710-6 10022-68-1
10325-94-7
2018/1/15 Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
ED 01/2018
65 Chrysene 205-923-4 218-01-9
1719-03-5
2018/1/15 Carcinogenic (Article 57a)
PBT (Article 57d)
vPvB (Article 57e)
ED 01/2018
66 1,6,7,8,9,14,15,16,17,17,18,18- Dodecachloropentacyclo[12.2.1.16,9.02,13.05,10]octadeca-7,15-diene (“Dechlorane Plus”™) [covering any of its individual anti- and syn-isomers or any combination thereof] - - 2018/1/15 vPvB (Article 57e) ED 01/2018
67 Reaction products of 1,3,4-thiadiazolidine-2,5-dithione, formaldehyde and 4-heptylphenol, branched and linear (RP-HP) [with ≥0.1% w/w 4-heptylphenol, branched and linear (4-HPbl)] - - 2018/1/15 Endocrine disrupting properties (Article 57(f) - environment) ED 01/2018
68 Perfluorohexane-1-sulphonic acid and its salts - - 2017/7/7 vPvB (Article 57e) ED/30/2017
69 4,4’-isopropylidenediphenol (bisphenol A; BPA) 201-245-8 80-05-7 2017/1/12 Toxic for reproduction (Article 57c)
Endocrine disrupting properties (Article 57(f) - human health)
Endocrine disrupting properties (Article 57(f) - environment)
ED/01/2017
ED/30/2017
70 Nonadecafluorodecanoic acid (PFDA) and its sodium and ammonium salts 206-400-3
-
221-470-5
335-76-2
3830-45-3
3108-42-7
2017/1/12 Toxic for reproduction (Article 57c)
PBT (Article 57d)
ED/01/2017
71 p-(1,1-dimethylpropyl)phenol 201-280-9 80-46-6 2017/1/12 Equivalent level of concern having probable serious effects to environment  (Article 57f) ED/01/2017
72 4-heptylphenol, branched and linear
[substances with a linear and/or branched alkyl chain with a carbon number of 7 covalently bound predominantly in position 4 to phenol, covering also UVCB- and well-defined substances which include any of the individual isomers or a combination thereof]
- - 2017/1/12 Equivalent level of concern having probable serious effects to environment  (Article 57f) ED/01/2017
73 Benzo[def]chrysene ; Benzo[a]pyrene 200-028-5 50-32-8 2016/6/20 Carcinogenic (Article 57a)#Mutagenic (Article 57b)#Toxic for reproduction (Article 57c)#PBT (Article 57 d)#vPvB (Article 57 e) ED/21/2016
74 1,3-propanesultone 214-317-9 1120-71-4 2015/12/17 Carcinogenic (Article 57 a) ED/79/2015
75 2,4-di-tert-butyl-6-(5-chlorobenzotriazol-2-yl)phenol (UV-327) 223-383-8 3864-99-1 2015/12/17 vPvB (Article 57 e) ED/79/2015
76 2-(2H-benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)phenol (UV-350) 253-037-1 36437-37-3 2015/12/17 vPvB (Article 57 e) ED/79/2015
77 Nitrobenzene 202-716-0 98-95-3 2015/12/17 Toxic for reproduction (Article 57 c) ED/79/2015
78 Perfluorononan-1-oic-acid and its sodium and ammonium salts 206-801-3 375-95-1
21049-39-8
4149-60-4
2015/12/17 Toxic for reproduction (Article 57 c)
PBT (Article 57 d)
ED/79/2015
79 1,2-benzenedicarboxylic acid, di-C6-10-alkyl esters; 1,2-benzenedicarboxylic acid, mixed decyl and hexyl and octyl diesters with ≥ 0.3% of dihexyl phthalate (EC No. 201-559-5) 271-094-0; 272-013-1 68515-51-5; 68648-93-1 2015/6/15 Toxic for reproduction (Article 57 c) ED/39/2015
80 5-sec-butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [1], 5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [2] [covering any of the individual stereoisomers of [1] and [2] or any combination thereof]     2015/6/15 vPvB (Article 57e) ED/39/2015
81 2-(2H-benzotriazol-2-yl)-4,6-ditertpentylphenol (UV-328) 247-384-8 25973-55-1 2014/12/17 PBT (Article 57 d); vPvB (Article 57 e) ED/108/2014
82 2-benzotriazol-2-yl-4,6-di-tert-butylphenol (UV-320) 223-346-6 3846-71-7 2014/12/17 PBT (Article 57 d); vPvB (Article 57 e) ED/108/2014
83 reaction mass of 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate and 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (reaction mass of DOTE and MOTE) - - 2014/12/17 Toxic for reproduction (Article 57 c) ED/108/2014
84 Cadmium fluoride 232-222-0 7790-79-6 2014/12/17 Carcinogenic (Article 57 a); Mutagenic (Article 57 b); Toxic for reproduction (Article 57 c); Equivalent level of concern having probable serious effects to human health (Article 57 f) ED/108/2014
85 Cadmium sulphate 233-331-6 10124-36-4,31119-53-6 2014/12/17 Carcinogenic (Article 57 a); Mutagenic (Article 57 b); Toxic for reproduction (Article 57 c); Equivalent level of concern having probable serious effects to human health (Article 57 f) ED/108/2014
86 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (DOTE) 239-622-4 15571-58-1 2014/12/17 Toxic for reproduction (Article 57 c) ED/108/2014
87 Cadmium chloride 233-296-7 10108-64-2 2014/6/16 Carcinogenic (Article 57a); Mutagenic (Article 57b); Toxic for reproduction (Article 57c); Equivalent level of concern having probable serious effects to human health (Article 57 f) ED/49/2014
88 1,2-Benzenedicarboxylic acid, dihexyl ester, branched and linear 271-093-5 68515-50-4 2014/6/16 Toxic for reproduction (Article 57 c) ED/49/2014
89 Sodium peroxometaborate 231-556-4 7632-04-4 2014/6/16 Toxic for reproduction (Article 57 c) ED/49/2014
90 Sodium perborate; perboric acid, sodium salt 239-172-9; 234-390-0 - 2014/6/16 Toxic for reproduction (Article 57 c) ED/49/2014
91 Cadmium sulphide 215-147-8 1306-23-6 2013/12/16 Carcinogenic (Article 57a); Equivalent level of concern having probable serious effects to human health (Article 57 f) ED/121/2013
92 Disodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis(4-aminonaphthalene-1-sulphonate) (C.I. Direct Red 28) 209-358-4 573-58-0 2013/12/16 Carcinogenic (Article 57a); ED/121/2013
93 Disodium 4-amino-3-[[4'-[(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo] -5-hydroxy-6-(phenylazo)naphthalene-2,7-disulphonate (C.I. Direct Black 38) 217-710-3 1937-37-7 2013/12/16 Carcinogenic (Article 57a); ED/121/2013
94 Dihexyl phthalate 201-559-5 84-75-3 2013/12/16 Toxic for reproduction (Article 57 c); ED/121/2013
95 Imidazolidine-2-thione; (2-imidazoline-2-thiol) 202-506-9 96-45-7 2013/12/16 Toxic for reproduction (Article 57 c); ED/121/2013
96 Lead di(acetate) 206-104-4 301-04-2 2013/12/16 Toxic for reproduction (Article 57 c); ED/121/2013
97 Trixylyl phosphate 246-677-8 25155-23-1 2013/12/16 Toxic for reproduction (Article 57 c); ED/121/2013
98 Cadmium 231-152-8 7440-43-9 20/6/2013 Carcinogenic (Article 57a); Equivalent level of concern having probable serious effects to human health (Article 57 f) ED/69/2013
99 Ammonium pentadecafluorooctanoate (APFO) 223-320-4 3825-26-1 2013/6/20 Toxic for reproduction (Article 57 c); PBT (Article 57 d) ED/69/2013
100 Pentadecafluorooctanoic acid (PFOA) 206-397-9 335-67-1 2013/6/20 Toxic for reproduction (Article 57 c); PBT (Article 57 d) ED/69/2013
101 Dipentyl phthalate (DPP) 205-017-9 131-18-0 2013/6/20 Toxic for reproduction (Article 57 c); ED/69/2013
102 4-Nonylphenol, branched and linear, ethoxylated [substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, ethoxylated covering UVCB- and well-defined substances, polymers and homologues, which include any of the individual isomers and/or combinations thereof]     2013/6/20 Equivalent level of concern having probable serious effects to the environment (Article 57 f) ED/69/2013
103 Cadmium oxide 215-146-2 1306-19-0 2013/6/20 Carcinogenic (Article 57a); Equivalent level of concern having probable serious effects to human health (Article 57 f) ED/69/2013
104 Hexahydromethylphthalic anhydride [1], Hexahydro-4-methylphthalic anhydride [2], Hexahydro-1-methylphthalic anhydride [3], Hexahydro-3-methylphthalic anhydride [4] [The individual isomers [2], [3] and [4] (including their cis- and trans- stereo isomeric forms) and all possible combinations of the isomers [1] are covered by this entry] 247-094-1, 243-072-0, 256-356-4, 260-566-1 25550-51-0, 19438-60-9, 48122-14-1, 57110-29-9 2012/12/19 Equivalent level of concern having probable serious effects to human health (Article 57 f) ED/169/2012
105 6-methoxy-m-toluidine (p-cresidine) 204-419-1 120-71-8 2012/12/19 Carcinogenic (Article 57a) ED/169/2012
106 Cyclohexane-1,2-dicarboxylic anhydride [1], cis-cyclohexane-1,2-dicarboxylic anhydride [2], trans-cyclohexane-1,2-dicarboxylic anhydride [3] [The individual cis- [2] and trans- [3] isomer substances and all possible combinations of the cis- and trans-isomers [1] are covered by this entry] 201-604-9, 236-086-3, 238-009-9 85-42-7, 13149-00-3, 14166-21-3 2012/12/19 Equivalent level of concern having probable serious effects to human health (Article 57 f) ED/169/2012
107 Pyrochlore, antimony lead yellow 232-382-1 8012-00-8 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
108 Henicosafluoroundecanoic acid 218-165-4 2058-94-8 2012/12/19 vPvB (Article 57 e) ED/169/2012
109 4-Aminoazobenzene 200-453-6 60-09-3 2012/12/19 Carcinogenic (Article 57a) ED/169/2012
110 Silicic acid, lead salt 234-363-3 11120-22-2 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
111 Lead titanium zirconium oxide 235-727-4 12626-81-2 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
112 Lead monoxide (lead oxide) 215-267-0 1317-36-8 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
113 o-Toluidine 202-429-0 95-53-4 2012/12/19 Carcinogenic (Article 57a) ED/169/2012
114 3-ethyl-2-methyl-2-(3-methylbutyl)-1,3-oxazolidine 421-150-7 143860-04-2 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
115 Dibutyltin dichloride (DBTC) 211-670-0 683-18-1 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
116 Lead bis(tetrafluoroborate) 237-486-0 13814-96-5 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
117 Lead dinitrate 233-245-9 10099-74-8 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
118 Silicic acid (H2Si2O5), barium salt (1:1), lead-doped [with lead (Pb) content above the applicable generic concentration limit for ’toxicity for reproduction’ Repr. 1A (CLP) or category 1 (DSD); the substance is a member of the group entry of lead compounds, with index number 082-001-00-6 in Regulation (EC) No 1272/2008] 272-271-5 68784-75-8 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
119 Trilead bis(carbonate)dihydroxide 215-290-6 1319-46-6 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
120 4,4'-methylenedi-o-toluidine 212-658-8 838-88-0 2012/12/19 Carcinogenic (Article 57a) ED/169/2012
121 Diethyl sulphate 200-589-6 64-67-5 2012/12/19 Carcinogenic (Article 57a); Mutagenic (Article 57b) ED/169/2012
122 Dimethyl sulphate 201-058-1 77-78-1 2012/12/19 Carcinogenic (Article 57a) ED/169/2012
123 N,N-dimethylformamide 200-679-5 68-12-2 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
124 4-(1,1,3,3-tetramethylbutyl)phenol, ethoxylated [covering well-defined substances and UVCB substances, polymers and homologues] - - 2012/12/19 Equivalent level of concern having probable serious effects to the environment (Article 57 f) ED/169/2012
125 4-Nonylphenol, branched and linear [substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, covering also UVCB- and well-defined substances which include any of the individual isomers or a combination thereof] - - 2012/12/19 Equivalent level of concern having probable serious effects to the environment (Article 57 f) ED/169/2012
126 Furan 203-727-3 110-00-9 2012/12/19 Carcinogenic (Article 57a) ED/169/2012
127 Lead oxide sulfate 234-853-7 12036-76-9 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
128 Lead titanium trioxide 235-038-9 12060-00-3 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
129 Bis(pentabromophenyl) ether (decabromodiphenyl ether; DecaBDE) 214-604-9 1163-19-5 2012/12/19 PBT (Article 57 d); vPvB (Article 57 e) ED/169/2012
130 Dinoseb (6-sec-butyl-2,4-dinitrophenol) 201-861-7 88-85-7 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
131 1,2-Diethoxyethane 211-076-1 629-14-1 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
132 N-methylacetamide 201-182-6 79-16-3 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
133 Tetralead trioxide sulphate 235-380-9 12202-17-4 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
134 Acetic acid, lead salt, basic 257-175-3 51404-69-4 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
135 [Phthalato(2-)]dioxotrilead 273-688-5 69011-06-9 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
136 Tetraethyllead 201-075-4 78-00-2 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
137 N-pentyl-isopentylphthalate - 776297-69-9 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
138 Pentalead tetraoxide sulphate 235-067-7 12065-90-6 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
139 Heptacosafluorotetradecanoic acid 206-803-4 376-06-7 2012/12/19 vPvB (Article 57 e) ED/169/2012
140 Tricosafluorododecanoic acid 206-203-2 307-55-1 2012/12/19 vPvB (Article 57 e) ED/169/2012
141 1-bromopropane (n-propyl bromide) 203-445-0 106-94-5 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
142 Dioxobis(stearato)trilead 235-702-8 12578-12-0 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
143 Pentacosafluorotridecanoic acid 276-745-2 72629-94-8 2012/12/19 vPvB (Article 57 e) ED/169/2012
144 Methoxyacetic acid 210-894-6 625-45-6 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
145 Methyloxirane (Propylene oxide) 200-879-2 75-56-9 2012/12/19 Carcinogenic (Article 57a); Mutagenic (Article 57b) ED/169/2012
146 Trilead dioxide phosphonate 235-252-2 12141-20-7 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
147 o-aminoazotoluene 202-591-2 97-56-3 2012/12/19 Carcinogenic (Article 57a) ED/169/2012
148 4-methyl-m-phenylenediamine (toluene-2,4-diamine) 202-453-1 95-80-7 2012/12/19 Carcinogenic (Article 57a) ED/169/2012
149 Diisopentylphthalate 210-088-4 605-50-5 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
150 1,2-Benzenedicarboxylic acid, dipentylester, branched and linear 284-032-2 84777-06-0 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
151 Biphenyl-4-ylamine 202-177-1 92-67-1 2012/12/19 Carcinogenic (Article 57a) ED/169/2012
152 Fatty acids, C16-18, lead salts 292-966-7 91031-62-8 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
153 Orange lead (lead tetroxide) 215-235-6 1314-41-6 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
154 4,4'-oxydianiline and its salts 202-977-0 101-80-4 2012/12/19 Carcinogenic (Article 57a); Mutagenic (Article 57b) ED/169/2012
155 Diazene-1,2-dicarboxamide (C,C'-azodi(formamide)) 204-650-8 123-77-3 2012/12/19 Equivalent level of concern having probable serious effects to human health (Article 57 f) ED/169/2012
156 Sulfurous acid, lead salt, dibasic 263-467-1 62229-08-7 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
157 Lead cyanamidate 244-073-9 20837-86-9 2012/12/19 Toxic for reproduction (Article 57 c) ED/169/2012
158 α,α-Bis[4-(dimethylamino)phenyl]-4 (phenylamino)naphthalene-1-methanol (C.I. Solvent Blue 4) [with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)] 229-851-8 6786-83-0 2012/6/18 Carcinogenic (Article 57a) ED/87/2012
159 1,3,5-tris[(2S and 2R)-2,3-epoxypropyl]-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione (β-TGIC) 423-400-0 59653-74-6 2012/6/18 Mutagenic (Article 57b) ED/87/2012
160 N,N,N',N'-tetramethyl-4,4'-methylenedianiline (Michler’s base) 202-959-2 101-61-1 2012/6/18 Carcinogenic (Article 57a) ED/87/2012
161 Diboron trioxide 215-125-8 1303-86-2 2012/6/18 Toxic for reproduction (Article 57 c) ED/87/2012
162 1,2-bis(2-methoxyethoxy)ethane (TEGDME; triglyme) 203-977-3 112-49-2 2012/6/18 Toxic for reproduction (Article 57 c) ED/87/2012
163 Formamide 200-842-0 75-12-7 2012/6/18 Toxic for reproduction (Article 57 c) ED/87/2012
164 4,4'-bis(dimethylamino)-4''-(methylamino)trityl alcohol [with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)] 209-218-2 561-41-1 2012/6/18 Carcinogenic (Article 57a) ED/87/2012
165 Lead(II) bis(methanesulfonate) 401-750-5 17570-76-2 2012/6/18 Toxic for reproduction (Article 57 c) ED/87/2012
166 [4-[4,4'-bis(dimethylamino) benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride (C.I. Basic Violet 3) [with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)] 208-953-6 548-62-9 2012/6/18 Carcinogenic (Article 57a) ED/87/2012
167 1,2-dimethoxyethane; ethylene glycol dimethyl ether (EGDME) 203-794-9 110-71-4 2012/6/18 Toxic for reproduction (Article 57 c) ED/87/2012
168 [4-[[4-anilino-1-naphthyl][4-(dimethylamino)phenyl]methylene]cyclohexa-2,5-dien-1-ylidene] dimethylammonium chloride (C.I. Basic Blue 26) [with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)] 219-943-6 2580-56-5 2012/6/18 Carcinogenic (Article 57a) ED/87/2012
169 1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC) 219-514-3 2451-62-9 2012/6/18 Mutagenic (Article 57b) ED/87/2012
170 4,4'-bis(dimethylamino)benzophenone (Michler’s ketone) 202-027-5 90-94-8 2012/6/18 Carcinogenic (Article 57a) ED/87/2012
171 Phenolphthalein 201-004-7 77-09-8 2011/12/19 Carcinogenic (article 57 a) ED/77/2011
172 N,N-dimethylacetamide 204-826-4 127-19-5 2011/12/19 Toxic for reproduction (article 57 c) ED/77/2011
173 4-(1,1,3,3-tetramethylbutyl)phenol 205-426-2 140-66-9 2011/12/19 Equivalent level of concern having probable serious effects to the environment (article 57 f) ED/77/2011
174 Lead diazide, Lead azide 236-542-1 13424-46-9 2011/12/19 Toxic for reproduction (article 57 c), ED/77/2011
175 Lead dipicrate 229-335-2 6477-64-1 2011/12/19 Toxic for reproduction (article 57 c) ED/77/2011
176 1,2-dichloroethane 203-458-1 107-06-2 2011/12/19 Carcinogenic (article 57 a) ED/77/2011
177 Calcium arsenate 231-904-5 7778-44-1 2011/12/19 Carcinogenic (article 57 a) ED/77/2011
178 Dichromium tris(chromate) 246-356-2 24613-89-6 2011/12/19 Carcinogenic (article 57 a) ED/77/2011
179 2-Methoxyaniline; o-Anisidine 201-963-1 90-04-0 2011/12/19 Carcinogenic (article 57 a) ED/77/2011
180 Pentazinc chromate octahydroxide 256-418-0 49663-84-5 2011/12/19 Carcinogenic (article 57 a) ED/77/2011
181 Zirconia Aluminosilicate Refractory Ceramic Fibres are fibres covered by index number 650-017-00-8 in Annex VI, part 3, table 3.1 of Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, and fulfil the three following conditions: a) oxides of aluminium, silicon and zirconium are the main components present (in the fibres) within variable concentration ranges b) fibres have a length weighted geometric mean diameter less two standard geometric errors of 6 or less micrometres (µm). c) alkaline oxide and alkali earth oxide (Na2O+K2O+CaO+MgO+BaO) content less or equal to 18% by weight - - 2011/12/19 Carcinogenic (article 57 a) ED/77/2011,ED/95/2012
182 Arsenic acid 231-901-9 7778-39-4 2011/12/19 Carcinogenic (article 57 a) ED/77/2011
183 Potassium hydroxyoctaoxodizincatedichromate 234-329-8 11103-86-9 2011/12/19 Carcinogenic (article 57 a) ED/77/2011
184 Formaldehyde, oligomeric reaction products with aniline 500-036-1 25214-70-4 2011/12/19 Carcinogenic (article 57 a) ED/77/2011
185 Lead styphnate 239-290-0 15245-44-0 2011/12/19 Toxic for reproduction (article 57 c) ED/77/2011
186 Bis(2-methoxyethyl) phthalate 204-212-6 117-82-8 2011/12/19 Toxic for reproduction (article 57 c) ED/77/2011
187 Trilead diarsenate 222-979-5 3687-31-8 2011/12/19 Carcinogenic and toxic for reproduction (articles 57 a and 57 c) ED/77/2011
188 Aluminosilicate Refractory Ceramic Fibres are fibres covered by index number 650-017-00-8 in Annex VI, part 3, table 3.1 of Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, and fulfil the three following conditions: a) oxides of aluminium and silicon are the main components present (in the fibres) within variable concentration ranges b) fibres have a length weighted geometric mean diameter less two standard geometric errors of 6 or less micrometres (µm) c) alkaline oxide and alkali earth oxide (Na2O+K2O+CaO+MgO+BaO) content less or equal to 18% by weight - - 2011/12/19 Carcinogenic (article 57 a) ED/77/2011,ED/95/2012
189 Bis(2-methoxyethyl) ether 203-924-4 111-96-6 2011/12/19 Toxic for reproduction (article 57 c) ED/77/2011
190 2,2'-dichloro-4,4'-methylenedianiline 202-918-9 101-14-4 2011/12/19 Carcinogenic (article 57 a) ED/77/2011
191 Cobalt dichloride 231-589-4 7646-79-9 2011/06/20 - 2008/10/28 Carcinogenic and toxic for reproduction (articles 57 a and 57 c) ED/31/2011 / ED/67/2008
192 1,2-Benzenedicarboxylic acid, di-C6-8-branched alkyl esters, C7-rich 276-158-1 71888-89-6 2011/6/20 Toxic for reproduction (article 57c) ED/31/2011
193 Strontium chromate 232-142-6 7789-06-2 2011/6/20 Carcinogenic (article 57a) ED/31/2011
194 1,2-Benzenedicarboxylic acid, di-C7-11-branched and linear alkyl esters 271-084-6 68515-42-4 2011/6/20 Toxic for reproduction (article 57c) ED/31/2011
195 1-Methyl-2-pyrrolidone 212-828-1 872-50-4 2011/6/20 Toxic for reproduction (article 57c) ED/31/2011
196 1,2,3-Trichloropropane 202-486-1 96-18-4 2011/6/20 Carcinogenic and toxic for reproduction (articles 57 a and 57 c) ED/31/2011
197 2-Ethoxyethyl acetate 203-839-2 111-15-9 2011/6/20 Toxic for reproduction (article 57c) ED/31/2011
198 Hydrazine 206-114-9 302-01-2, 7803-57-8 2011/6/20 Carcinogenic (article 57a) ED/31/2011
199 Cobalt(II) diacetate 200-755-8 71-48-7 2010/12/15 Carcinogenic and toxic for reproduction (articles 57 a and 57 c) ED/95/2010
200 2-Ethoxyethanol 203-804-1 110-80-5 2010/12/15 Toxic for reproduction (article 57c) ED/95/2010
201 Cobalt(II) sulphate 233-334-2 10124-43-3 2010/12/15 Carcinogenic and toxic for reproduction (articles 57 a and 57 c) ED/95/2010
202 Acids generated from chromium trioxide and their oligomers. Names of the acids and their oligomers: Chromic acid, Dichromic acid, Oligomers of chromic acid and dichromic acid. 231-801-5, 236-881-5 7738-94-5, 13530-68-2 2010/12/15 Carcinogenic (article 57a) ED/95/2010
203 2-Methoxyethanol 203-713-7 109-86-4 2010/12/15 Toxic for reproduction (article 57c) ED/95/2010
204 Chromium trioxide 215-607-8 1333-82-0 2010/12/15 Carcinogenic and mutagenic (articles 57 a and 57 b) ED/95/2010
205 Cobalt(II) carbonate 208-169-4 513-79-1 2010/12/15 Carcinogenic and toxic for reproduction (articles 57 a and 57 c) ED/95/2010
206 Cobalt(II) dinitrate 233-402-1 10141-05-6 2010/12/15 Carcinogenic and toxic for reproduction (articles 57 a and 57 c) ED/95/2010
207 Trichloroethylene 201-167-4 79-01-6 2010/6/18 Carcinogenic (article 57 a) ED/30/2010
208 Potassium dichromate 231-906-6 7778-50-9 2010/6/18 Carcinogenic, mutagenic and toxic for reproduction (articles 57 a, 57 b and 57 c) ED/30/2010
209 Tetraboron disodium heptaoxide, hydrate 235-541-3 12267-73-1 2010/6/18 Toxic for reproduction (article 57 c) ED/30/2010
210 Boric acid 233-139-2, 234-343-4 10043-35-3, 11113-50-1 2010/6/18 Toxic for reproduction (article 57 c) ED/30/2010
211 Ammonium dichromate 232-143-1 7789-09-5 2010/6/18 Carcinogenic, mutagenic and toxic for reproduction (articles 57 a, 57 b and 57 c) ED/30/2010
212 Sodium chromate 231-889-5 7775-11-3 2010/6/18 Carcinogenic, mutagenic and toxic for reproduction (articles 57 a, 57 b and 57 c) ED/30/2010
213 Disodium tetraborate, anhydrous 215-540-4 1303-96-4, 1330-43-4, 12179-04-3 2010/6/18 Toxic for reproduction (article 57 c) ED/30/2010
214 Potassium chromate 232-140-5 7789-00-6 2010/6/18 Carcinogenic and mutagenic (articles 57 a and 57 b). ED/30/2010
215 Acrylamide 201-173-7 79-06-1 2010/3/30 Carcinogenic and mutagenic (articles 57 a and 57 b) ED/68/2009
216 Lead sulfochromate yellow (C.I. Pigment Yellow 34) 215-693-7 1344-37-2 2010/1/13 Carcinogenic and toxic for reproduction (articles 57 a and 57 c)) ED/68/2009
217 Lead chromate molybdate sulphate red (C.I. Pigment Red 104) 235-759-9 12656-85-8 2010/1/13 Carcinogenic and toxic for reproduction (articles 57 a and 57 c) ED/68/2009
218 2,4-Dinitrotoluene 204-450-0 121-14-2 2010/1/13 Carcinogenic (article 57a) ED/68/2009
219 Anthracene oil 292-602-7 90640-80-5 2010/1/13 Carcinogenic1, PBT and vPvB (articles 57a, 57d and 57e) ED/68/2009
220 Anthracene oil, anthracene paste, anthracene fraction 295-275-9 91995-15-2 2010/1/13 Carcinogenic2, mutagenic3, PBT and vPvB (articles 57a, 57b, 57d and 57e) ED/68/2009
221 Anthracene oil, anthracene-low 292-604-8 90640-82-7 2010/1/13 Carcinogenic2, mutagenic3, PBT and vPvB (articles 57a, 57b, 57d and 57e) ED/68/2009
222 Diisobutyl phthalate (DIBP) 201-553-2 84-69-5 2010/1/13 Toxic for reproduction (article 57c)
Endocrine disrupting properties (Article 57(f) - human health)
ED/68/2009
C(2017)4462
ED/30/2017
223 Tris(2-chloroethyl)phosphate 204-118-5 115-96-8 2010/1/13 Toxic for reproduction (article 57c) ED/68/2009
224 Lead chromate 231-846-0 7758-97-6 2010/1/13 Carcinogenic and toxic for reproduction (articles 57 a and 57 c) ED/68/2009
225 Anthracene oil, anthracene paste 292-603-2 90640-81-6 2010/1/13 Carcinogenic2, mutagenic3, PBT and vPvB (articles 57a, 57b, 57d and 57e) ED/68/2009
226 Pitch, coal tar, high temp. 266-028-2 65996-93-2 2010/1/13 Carcinogenic, PBT and vPvB (articles 57a, 57d and 57e) ED/68/2009
227 Anthracene oil, anthracene paste,distn. lights 295-278-5 91995-17-4 2010/1/13 Carcinogenic2, mutagenic3, PBT and vPvB (articles 57a, 57b, 57d and 57e) ED/68/2009
228 Lead hydrogen arsenate 232-064-2 7784-40-9 2008/10/28 Carcinogenic and toxic for reproduction (articles 57 a and 57 c) ED/67/2008
229 Benzyl butyl phthalate (BBP) 201-622-7 85-68-7 2008/10/28 Toxic for reproduction (article 57c)
Endocrine disrupting properties (Article 57(f) - human health)
ED/67/2008
C(2017)4462
ED/30/2017
230 Bis(2-ethylhexyl) phthalate (DEHP) 204-211-0 117-81-7 2014/12/17; 2008/10/28 Toxic for reproduction (Article 57c)
Endocrine disrupting properties (Article 57(f) - environment)
Endocrine disrupting properties (Article 57(f) - human health)
ED/67/2008
ED/108/2014
C(2017)4462
ED/30/2017
231 Bis(tributyltin)oxide (TBTO) 200-268-0 56-35-9 2008/10/28 PBT (article 57d) ED/67/2008
232 5-tert-butyl-2,4,6-trinitro-m-xylene (musk xylene) 201-329-4 81-15-2 2008/10/28 vPvB (article 57e) ED/67/2008
233 Diarsenic trioxide 215-481-4 1327-53-3 2008/10/28 Carcinogenic (article 57a) ED/67/2008
234 Triethyl arsenate 427-700-2 15606-95-8 2008/10/28 Carcinogenic (article 57a) ED/67/2008
235 Diarsenic pentaoxide 215-116-9 1303-28-2 2008/10/28 Carcinogenic (article 57a) ED/67/2008
236 Sodium dichromate 234-190-3 7789-12-0, 10588-01-9 2008/10/28 Carcinogenic, mutagenic and toxic for reproduction (articles 57a, 57b and 57c) ED/67/2008
237 Dibutyl phthalate (DBP) 201-557-4 84-74-2 2008/10/28 Toxic for reproduction (Article 57c)
Endocrine disrupting properties (Article 57(f) - environment)
Endocrine disrupting properties (Article 57(f) - human health)
EU/2017/4462
D(2023)8585-DC
ED/30/2017
ED/67/2008
238 4,4'- Diaminodiphenylmethane (MDA) 202-974-4 101-77-9 2008/10/28 Carcinogenic (article 57a) ED/67/2008
239 Alkanes, C10-13, chloro (Short Chain Chlorinated Paraffins) 287-476-5 85535-84-8 2008/10/28 PBT and vPvB (articles 57 d and 57 e) ED/67/2008
240 Anthracene 204-371-1 120-12-7 2008/10/28 PBT (article 57d) ED/67/2008
241 Hexabromocyclododecane (HBCDD) and all major diastereoisomers identified: Alpha-hexabromocyclododecane Beta-hexabromocyclododecane Gamma-hexabromocyclododecane 247-148-4 and 221-695-9 25637-99-4, 3194-55-6 (134237-50-6) (134237-51-7) (134237-52-8) 2008/10/28 PBT (article 57d) ED/67/2008